Lamivudine Intermediates

1. L-Menthyl glyoxylate hydrate(L-MGH)

2. (1R,2S,5R)-Menthyl-5R-hydroxy-1,3-oxathiolane-2R-carboxylate(HME)

3. (2R,5R)-5-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-[1,3]oxathiolane-2-carboxylic acid,2S-
isopropyl-5-R-methyl-1R-cyclohexyl ester(CME)

4. (2R-Cis)-4-amino-1[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone
salicylate monohydrate(Lamivudine Salicylate)