Chinese | English
Home > API > Pvraloximi Chloridum Pvraloximi Chloridum

Product name: Pvraloximi Chloridum
Pralidoxime or 2-PAM, usually as the chloride or methiodide salts, belongs to a family of compounds called oximes that bind to organophosphate-inactivated acetylcholinesterase. It is used to combat poisoning by organophosphates or acetylcholinesterase inhibitors (nerve agents), in conjunction with atropine and diazepam.

Pralidoxime reversibly binds to the enzyme acetylcholinesterase, competing with organophosphate binding. However, 2-PAM does not inactivate the enzyme and is therefore thought to dislodge or block organophosphates from inactivating acetylcholinesterase. However, organophosphates ultimately irreversibly bind to acetylcholinesterase, requiring early administration of 2-PAM. Note that meta-analyses of the use of "-oximes" (like 2-PAM) in organophosphate poisoning have not demonstrated any benefit (and their use may be harmful). There are no controlled studies.